Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease

YILDIRIM E., AKTÜRK T., HANOĞLU L., Yener G., Babiloni C., GÜNTEKİN B.

Neurobiology of Aging, cilt.137, ss.78-93, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 137
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.neurobiolaging.2024.02.004
  • Dergi Adı: Neurobiology of Aging
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Abstracts in Social Gerontology, BIOSIS, CAB Abstracts, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.78-93
  • Anahtar Kelimeler: Dementia, Alzheimer's disease (AD), Dementia with Lewy Bodies (DLB), Parkinson's disease (PD), Electroencephalography (EEG), Event-Related Oscillations (EROs)
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Oddball task-related EEG delta and theta responses are associated with frontal executive functions, which are significantly impaired in patients with dementia due to Parkinson's disease (PDD) and Lewy bodies (DLB). The present study investigated the oddball task-related EEG delta and theta responses in patients with PDD, DLB, and Alzheimer's disease dementia (ADD). During visual and auditory oddball paradigms, EEG activity was recorded in 20 ADD, 17 DLB, 20 PDD, and 20 healthy (HC) older adults. Event-related EEG power spectrum and phase-locking analysis were performed at the delta (1–4 Hz) and theta (4–7 Hz) frequency bands for target and nontarget stimuli. Compared to the HC persons, dementia groups showed lower frontal and central delta and theta power and phase-locking associated with task performance and neuropsychological test scores. Notably, this effect was more significant in the PDD and DLB than in the ADD. In conclusion, oddball task-related frontal and central EEG delta and theta responses may reflect frontal supramodal executive dysfunctions in PDD and DLB patients.