Vitamin B12 levels in familial Mediterranean fever patients treated with colchicine

Gemici A. I., Sevindik O. G., Akar S., Tunca M.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.31, no.3, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2013
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: familial Mediterranean fever, autoinflammatory disease, colchicine, vitamin B12
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives. Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterised by paroxysmal attacks of serosal inflammation. Colchicine is highly effective in preventing these attacks but it may also disrupt the intestinal absorption of vitamin B12. We hypothesised that patients treated with colchicine for a prolonged period could develop deficiency of the vitamin.