The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose

Baykal, Mehmet; Gokmen, ALİ; Dogan, Alper; Erbayraktar, REŞAT; YILMAZ, OSMAN; ÖÇMEN, ELVAN; AKSU ERDOST, HALE; Arkan, Atalay

doi:10.1016/j.bjane.2015.02.010

The effects of intra-cerebroventricular administered rocuronium on the central nervous system of rats and determination of its epileptic seizure-inducing dose

Atıf İçin Kopyala

Baykal M., Gokmen N., Dogan A., Erbayraktar S., YILMAZ O., ÖÇMEN E., ...Daha Fazla

REVISTA BRASILEIRA DE ANESTESIOLOGIA, cilt.67, sa.1, ss.1-5, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 67 Sayı: 1
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.bjane.2015.02.010
Dergi Adı: REVISTA BRASILEIRA DE ANESTESIOLOGIA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1-5
Anahtar Kelimeler: Rocuronium, Seizure, Central nervous system, Rat, CEREBROSPINAL-FLUID, INJECTION, LAUDANOSINE, VECURONIUM, ATRACURIUM
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: The aim of this study was to investigate the effects of intracerebroventricularly administered rocuronium bromide on the central nervous system, determine the seizure threshold dose of rocuronium bromide in rats, and investigate the effects of rocuronium on the central nervous system at 1/5, 1/10, and 1/100 dilutions of the determined seizure threshold dose.