An Analysis on Coronary Artery Disease Severity with Serum Adropin Level in Patients with Acute ST-Segment Elevation Myocardial Infarction

Creative Commons License


Sakarya Tıp Dergisi, vol.10, no.4, pp.623-628, 2020 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.31832/smj.767212
  • Journal Name: Sakarya Tıp Dergisi
  • Page Numbers: pp.623-628
  • Dokuz Eylül University Affiliated: No


Objective Adropin is associated with energy balance in tissues and organs. The SYNTAX score (SS) is used to determine the severity of ST-segment elevation myocardial infarction(STEMI). The aim of this study was to determine the relationship between serum adropin levels and disease severity in STEMI patients.Materialsand MethodsEighty-nine patients who underwent coronary angiography (CAG) for STEMI were included in the study. The STEMI patients were divided into two subgroups: Group 1(SS< 22) and Group 2 (SS ≥ 23). 43 patients who underwent CAG and had normal coronary arteries were included in the study as a control group.Results Groups 1 and 2 included more male participants than the control group (89.7% and 74.2% vs. 34.9%, respectively, p < 0.001). The smoking rate was higher in Groups 1 and2 than in the control group (55.1% and 34.4% vs. 11.6%, respectively, p≤0.001). Serum adropin levels were lower in Group 1 than in the control group (147.3 ± 149.2 mg/Land 228.1 ± 253.3 ng/L, p = 0.03). Serum adropin levels were the lowest in Group 2 (87.8 ± 23.2 ng/L, 147.3 ± 149.2 ng/L, and 228.1 ± 253.3 ng/L, p = 0.004). Serum adropinlevels were also negatively correlated with SS (r = -0.33, p = 0.002).Conclusion Serum adropin levels decreased more in STEMI patients than in those without coronary artery disease (CAD). In addition, serum adropin levels decreased with increasingSS;this indicates the severity of CAD.