Deferoxamine and meropenem combination therapy in experimental acute pancreatitis.

Ateskan U., Mas M., Yasar M., Deveci S., Babaoglu E., Comert B., ...Daha Fazla

Pancreas, cilt.27, sa.3, ss.247-52, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/00006676-200310000-00010
  • Dergi Adı: Pancreas
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.247-52
  • Anahtar Kelimeler: acute pancreatitis, deferoxamine, meropenem, secondary infections, PLATELET-ACTIVATING-FACTOR, NECROTIZING PANCREATITIS, ANTIBIOTIC-PROPHYLAXIS, SURGICAL-TREATMENT, OXIDATIVE STRESS, TISSUE, RATS, PENETRATION, NEUTROPHILS, NECROSIS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Introduction: Recent data from the experimental clinical studies suggest that antibiotics having good penetration to pancreas may reduce mortality by preventing pancreatic infection, which is the most important prognostic factor in acute pancreatitis (AP). Deferoxamine is an active free oxygen radical scavenger, which has been shown to have a protective role in development of acute pancreatitis.