Deferoxamine and meropenem combination therapy in experimental acute pancreatitis.

Ateskan U., Mas M., Yasar M., Deveci S., Babaoglu E., Comert B., ...More

Pancreas, vol.27, no.3, pp.247-52, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1097/00006676-200310000-00010
  • Journal Name: Pancreas
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.247-52
  • Keywords: acute pancreatitis, deferoxamine, meropenem, secondary infections, PLATELET-ACTIVATING-FACTOR, NECROTIZING PANCREATITIS, ANTIBIOTIC-PROPHYLAXIS, SURGICAL-TREATMENT, OXIDATIVE STRESS, TISSUE, RATS, PENETRATION, NEUTROPHILS, NECROSIS
  • Dokuz Eylül University Affiliated: No

Abstract

Introduction: Recent data from the experimental clinical studies suggest that antibiotics having good penetration to pancreas may reduce mortality by preventing pancreatic infection, which is the most important prognostic factor in acute pancreatitis (AP). Deferoxamine is an active free oxygen radical scavenger, which has been shown to have a protective role in development of acute pancreatitis.