Mood disorders - review of structural MRI studies


Monkul E., Malhi G., Soares J.

ACTA NEUROPSYCHIATRICA, vol.15, no.6, pp.368-380, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 15 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1601-5215.2003.00052.x
  • Journal Name: ACTA NEUROPSYCHIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.368-380
  • Keywords: bipolar disorder, depression, magnetic resonance imaging, mood disorders, structural, BIPOLAR AFFECTIVE-DISORDER, GRAY-MATTER VOLUME, SUBGENUAL PREFRONTAL CORTEX, UNIPOLAR MAJOR DEPRESSION, SUBCORTICAL SIGNAL HYPERINTENSITIES, QUANTITATIVE CEREBRAL ANATOMY, NUCLEAR MAGNETIC-RESONANCE, COMORBID MEDICAL ILLNESS, WHITE-MATTER, GERIATRIC DEPRESSION
  • Dokuz Eylül University Affiliated: No

Abstract

Background: Mood disorders are related to considerable morbidity and mortality, and although there is little doubt that they are brain-based disorders, their neural correlates still remain elusive. A neuro-anatomic model of mood regulation comprising the prefrontal cortex, amygdalahippocampus complex, thalamus, basal ganglia, and connections among these areas has been proposed.