Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?


SARI İ., Igci Y. Z., Can G., Taylan A., Solmaz D., Gogebakan B., ...More

CLINICS, vol.68, no.3, pp.305-309, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.6061/clinics/2013(03)oa04
  • Journal Name: CLINICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.305-309
  • Keywords: Ankylosing Spondylitis, Endothelial Nitric Oxide Synthase, Nitric Oxide, Inflammation, Atherosclerosis, ASYMMETRIC DIMETHYLARGININE ADMA, CORONARY SPASM, DISEASE, ATHEROSCLEROSIS, INDEX, BATH, ASSOCIATION, PROMOTER, RISK
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction and increased asymmetric dimethylarginine, this study aimed to assess the association of common endothelial nitric oxide synthase gene polymorphisms with ankylosing spondylitis.