Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?

SARI İ., Igci Y. Z., Can G., Taylan A., Solmaz D., Gogebakan B., ...Daha Fazla

CLINICS, cilt.68, sa.3, ss.305-309, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.6061/clinics/2013(03)oa04
  • Dergi Adı: CLINICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.305-309
  • Anahtar Kelimeler: Ankylosing Spondylitis, Endothelial Nitric Oxide Synthase, Nitric Oxide, Inflammation, Atherosclerosis, ASYMMETRIC DIMETHYLARGININE ADMA, CORONARY SPASM, DISEASE, ATHEROSCLEROSIS, INDEX, BATH, ASSOCIATION, PROMOTER, RISK
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction and increased asymmetric dimethylarginine, this study aimed to assess the association of common endothelial nitric oxide synthase gene polymorphisms with ankylosing spondylitis.