Assessment of Rac1 and beta-PAK Expressions in a Mouse Model for Contrast-Induced Nephropathy
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.3, ss.230-236, 2020 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.30621/jbachs.2020.1057
- Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.230-236
- Anahtar Kelimeler: apoptosis, contrast-induced nephropathy, iohexol, mouse, Rac1
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Purpose: Radiocontrast-induced nephropathy is an important clinical problem in high-risk patients. The mechanism of cytotoxic effect of radiocontrast media on kidneys is still not fully clarified. Rac1/beta-PAK pathway has been shown to play a role in other nephropathies such as diabetic nephropathy. In this study, it was aimed to determine whether Rac1/beta-PAK signalling pathway has any role in the development of contrast-induced nephropathy (CIN).