Assessment of Rac1 and beta-PAK Expressions in a Mouse Model for Contrast-Induced Nephropathy

MANİSALIGİL Y. A., CİLAKER MIÇILI S., KIZILDAĞ S., BAĞRIYANIK H. A., GÜMÜŞTEKİN M., Celik A.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.3, ss.230-236, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30621/jbachs.2020.1057
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.230-236
  • Anahtar Kelimeler: apoptosis, contrast-induced nephropathy, iohexol, mouse, Rac1, RADIOCONTRAST-INDUCED NEPHROPATHY, KIDNEY INJURY, ACTIVATION, STRESS, FAMILY, RATS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Radiocontrast-induced nephropathy is an important clinical problem in high-risk patients. The mechanism of cytotoxic effect of radiocontrast media on kidneys is still not fully clarified. Rac1/beta-PAK pathway has been shown to play a role in other nephropathies such as diabetic nephropathy. In this study, it was aimed to determine whether Rac1/beta-PAK signalling pathway has any role in the development of contrast-induced nephropathy (CIN).