Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

Tunca Z., Resmi H., ÖZKARA H. A., Ciliv G., ÇELTİKÇİ B., ALPTEKİN K., ...Daha Fazla

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, sa.5, ss.1214-1220, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.pnpbp.2008.03.008
  • Dergi Adı: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1214-1220
  • Anahtar Kelimeler: extrapyramidal side effect, antipsychotic drug, hexosaminidase, ganglioside, dopamine, TAY-SACHS-DISEASE, TARDIVE-DYSKINESIA, GANGLIOSIDE TREATMENT, BETA-HEXOSAMINIDASE, GM1 GANGLIOSIDE, HALOPERIDOL, BRAIN, MONOSIALOGANGLIOSIDE, SUPERSENSITIVITY, LITHIUM
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities of A and B isoforms of hexosaminidase were higher in EPS-positive patients than EPS-negative patients and healthy controls. Multivariate analysis suggested an interaction with increased B isoform activity and EPS side effects in female bipolar disorder patients. Higher levels of hexosaminidase enzyme activity may explain the frequent occurrence of antipsychotic-induced extrapyramidal side effects in mood disorder patients. (C) 2008 Elsevier Inc. All rights reserved.