Akademik Veri Yönetim Sistemi
ECTRIMS, Vienna, Avusturya, 13 - 15 Kasım 2021, ss.259
Introduction: Even though the prevalence of restless leg syndrome (RLS) in multiple sclerosis (MS) is known to vary between 12.5% and 60%, depends on population, the underlying pathophysiological mechanism is not known precisely. However, several hypotheses about the pathophysiology and the presence of spinal cord lesions seem to play a critical role in all of them. Aim: Therefore, this study investigates the relationship between the presence of spinal cord lesions and RLS in MS. Methods: In total, 959 persons with MS (pwMS) were enrolled in this study. The diagnosis of RLS used the criteria defined by the International Restless Legs Syndrome Study Group. Demographic (gender, age, height, weight) and clinical data (disability level and disease duration) of pwMS were recorded by interviewing and medical records. MRI scans were evaluated by three neurologists who blind the presence of RLS. They recorded the presence or not of the lesion in the brainstem, cervical cord, and thoracic cord. Results: The RLS was detected in 222 participants (23.15%). RLS was not significantly linked to mean age, body mass index, gender, and MS duration, but pwMS with RLS have a higher disability level, which was statistically significant (p=0.044). In addition, no difference in the brainstem and thoracic cord was found between pwMS with and without RLS. At the same time, there is a significant relationship between the presence of cervical cord lesion and RLS (p=0.045, OR=1.564). Conclusion: This study has suggested that higher disability and cervical cord damage represent a significant risk factor for pwMS with RLS. Since considering the negative effects of RLS, the increased awareness and treatment of RLS among pwMS is essential for better managing.