Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.30, sa.2, ss.64-68, 2002 (Scopus)
In this study intubating conditions and neuromuscular blocking effects of rocuronium in patients scheduled for elective surgery and anaesthetized either with sevoflurane (n=21) or with TIVA (n=23) were studied. In Propofol-Rocuronium (P-R) group patients received 2 μg/kg fentanyl, 2 mg/kg propofol for induction and 5-10 mg/kg/h propofol, 4-10 μg/kg/h fentanyl infusion for maintenance. In Sevoflurane-Rocuronium (S-R) group patients received 2 μg/kg fentanyl, 2 mg/kg propofol for induction and sevoflurane for maintenance. 60 % N2O and 40 % O2 was used in all patients during maintenance of anaesthesia. Ten min after induction 0.6 mg/kg rocuronium was administered and patients were intubated. Neuromuscular block was monitored using train of four stimulation. Onset time, clinical duration (T25), recovery index (T25-75), spontaneous recovery time (T4/T1), and time to return of T1-T2-T3-T4 were recorded. T25 was 43.53±8.61 min in P-R group and 59.79±16.26 min in S-R group. T25-75 was 14.40±480 min in P-R group and 26.52±8.10 min in S-R group. T4/T1 was 61.48±14.72 min in P-R group and 101.99±15.17 min in S-R group. Time to return of T1 was 33.38±6.85 min in P-R group and 41.54±11.43 min in S-R group; T2 was 39.41±7.49 min in P-R group and 50.33±13.49 min in S-R group; T3 was 42.72±8.55 min in P-R group and 57.00±14.07 min in S-R group and T4 was 44.00±8.42 min in P-R group and 60.23±15.11 min in S-R group. The differences between the groups were statistically significant (p<0.05). It can be concluded that sevoflurane potentiates the neuromuscular blocking effect of rocuronium.