The relationship between human papillomavirus infection and cervical intraepithelial neoplasia in Turkish women

Inal M. M., Kose Ş., Yildirim Y., Ozdemir Y., Toz E., Ertopcu K., ...Daha Fazla

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, cilt.17, sa.6, ss.1266-1270, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1525-1438.2007.00944.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1266-1270
  • Anahtar Kelimeler: carcinogenesis, cervical intraepithelial neoplasia, human papillomavirus, Pap smear, Turkish women, ATYPICAL SQUAMOUS-CELLS, RISK HUMAN-PAPILLOMAVIRUS, HYBRID CAPTURE, UNDETERMINED SIGNIFICANCE, CYTOLOGY INTERPRETATIONS, RANDOMIZED-TRIAL, VIRAL LOAD, HPV TYPES, CANCER, MANAGEMENT
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

To compare the prevalence of cervical human papillomavirus (HPV) infection in Turkish women with normal Papanicolaou (Pap) smear and cervical intraepithelial neoplasia (CIN). In between March 2002 and November 2005, the study was designed as case-control study. Cytologic abnormalities in Pap smears were classified according to the Bethesda System (2001). Identification of the presence of HPV was carried out by the Hybrid Capture II test for all patients. To compare the groups, Chi-square test was used. A total of 1353 reproductive aged women were screened. Of them, 1344 (99.3%) had normal or class I Pap smear. Remaining nine cases (0.7%) had CIN at several degrees (five CIN I, three CIN II, and one carcinoma in situ). While all these nine cases with cervical pathologies had HPV, only 20 cases from the other group (1.5%) had HPV (chi(2) 466.1; P = 0.0001). This is the first study of the evaluation of the association between HPV and preinvasive cervical lesions in Turkish population. In spite of low general frequency (2.1%) of cervical HPV colonization in this population, a strong correlation was found between HPV and CIN.