Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy

Terzi C., Canda A. E., Sagol O., ATİLA K., Sonmez D., Fuzun M., ...Daha Fazla

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, cilt.23, sa.1, ss.37-45, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00384-007-0376-x
  • Dergi Adı: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.37-45
  • Anahtar Kelimeler: rectal cancer, preoperative chemoradiotherapy, radiosensitivity, p53, Ki-67, survivin, TOTAL MESORECTAL EXCISION, ANTI-APOPTOSIS GENE, MOLECULAR PROGNOSTIC-FACTORS, DISEASE-FREE SURVIVAL, HIGH-DOSE LEUCOVORIN, NEOADJUVANT RADIOCHEMOTHERAPY, CELL-DEATH, RADIORESISTANCE FACTOR, COLORECTAL-CARCINOMA, SURGICAL RESECTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The ability to predict response to chemoradiotherapy before the treatment may allow protecting poorly responding patients from the side effects of neoadjuvant treatment. Several molecular markers have been proposed to radio and chemosensitivity of rectal cancer. In this study, from pre-irradiation tumor biopsies, a novel and promising candidate factor survivin, and p53 and Ki-67 were assessed as predictors of response to preoperative chemoradiotherapy.