Renal failure in high altitude: renal functions, renal pathology and bone mineralization in rats with ablation nephropathy at 1200 m altitude.

SOYLU A., Kavukcu S., Yilmaz O., Astarcioglu H., Ozkal S., Turkmen M., ...Daha Fazla

Pathology, research and practice, cilt.203, sa.11, ss.795-800, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 203 Sayı: 11
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.prp.2007.08.002
  • Dergi Adı: Pathology, research and practice
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.795-800
  • Anahtar Kelimeler: altitude, ablation nephropathy, bone mineralization, rat, POLYCYTHEMIA, PROTEINURIA, HYPOXIA
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The effect of altitude on renal failure and bone mineralization is not well known. This topic is studied in a 5/6 nephrectomy rat model. After hemoglobin, creatinine clearance and proteinuria were determined in 28 Wistar rats. Two 5/6 nephrectomy (Nx1-Nx2, n = 7 each) and two sham (Sh1-Sh2, n = 7 each) groups were formed. The Nx1-Sh1 and Nx2-Sh2 groups were kept at sea level and at 1200m altitude, respectively. The same analyses were performed after 3 months just before sacrifices in order to harvest kidneys and femurs for histopathologic examination.