Toxic hepatitis associated with paroxetine

Colakoglu, O; Tankurt, E; Unsal, B; Ugur, F; Kupelioglu, A; Buyrac, Z; Akpinar, Z

doi:10.1111/j.1368-5031.2005.00572.x

Toxic hepatitis associated with paroxetine

Colakoglu O., Tankurt E., Unsal B., Ugur F., Kupelioglu A., Buyrac Z., ...Daha Fazla

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, cilt.59, sa.7, ss.861-862, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 7
Basım Tarihi: 2005
Doi Numarası: 10.1111/j.1368-5031.2005.00572.x
Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.861-862
Anahtar Kelimeler: paroxetine, toxic, hepatitis
Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Hepatotoxicity is a rare complication of paroxetine, a selective serotonin reuptake inhibitor. Regarded as safe in therapeutic use, there have been reports of cases of severe hepatic dysfunction with gross elevations of transaminase levels that may be related to this drug. We report here severe adverse cholestatic and hepatocellular injury in a patient taking paroxetine probably due to an immune-mediated hypersensitivity reaction.