Toxic hepatitis associated with paroxetine

Colakoglu O., Tankurt E., Unsal B., Ugur F., Kupelioglu A., Buyrac Z., ...More

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.59, no.7, pp.861-862, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 7
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1368-5031.2005.00572.x
  • Journal Name: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.861-862
  • Keywords: paroxetine, toxic, hepatitis, HEPATOTOXICITY
  • Dokuz Eylül University Affiliated: No

Abstract

Hepatotoxicity is a rare complication of paroxetine, a selective serotonin reuptake inhibitor. Regarded as safe in therapeutic use, there have been reports of cases of severe hepatic dysfunction with gross elevations of transaminase levels that may be related to this drug. We report here severe adverse cholestatic and hepatocellular injury in a patient taking paroxetine probably due to an immune-mediated hypersensitivity reaction.