Vitamin D receptor gene polymorphisms and haplotypes (Apa I, Bsm I, Fok I, Taq I) in Turkish psoriasis patients
MEDICAL SCIENCE MONITOR, vol.18, no.11, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 11
- Publication Date: 2012
- Doi Number: 10.12659/msm.883544
- Journal Name: MEDICAL SCIENCE MONITOR
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: haplotype, polymorphism, psoriasis, vitamin D, VDR, Turkish
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Background: Psoriasis is an inflammatory disease characterized by increased squamous cell proliferation and impaired differentiation. Vitamin D, Calcitriol, and its analogues are successfully used for psoriasis therapy. However, it is unknown why some psoriasis patients are resistant to Vitamin D therapy. Vitamin D mediates its activity by a nuclear receptor. It is suggested that polymorphisms and haplotypes in the VDR gene may explain the differences in response to vitamin D therapy.