Purpose: To present two immunocompetent patients with Aspergillus niger infection of the exenterated orbit. Methods: Case reports. Results: The patients were treated with oral itraconazole and socket irrigation with amphotericin B. The sockets cleared completely; no growth was observed on reculturing. Conclusions: A niger infection of an exenterated socket can be effectively treated with oral itraconazole and topical amphotericin B in immunocompetent patients.