Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study

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AKAY A., ERESEN YAZICIOĞLU Ç., ALŞEN GÜNEY S., Erkuran H. O., KIZILDAĞ S., BAYKARA H. B., ...More

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.28, no.2, pp.177-184, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1080/24750573.2017.1418134
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.177-184
  • Keywords: Attention deficit/hyperactivity disorder, adolescents, catechol-O-methyltransferase gene (COMT), dopamine D4 receptor gene (DRD4), methylphenidate, clinical global impression (CGI), DEFICIT HYPERACTIVITY DISORDER, III REPEAT POLYMORPHISM, HAPLOTYPE RELATIVE RISK, TRANSPORTER GENE, SUSTAINED ATTENTION, NO ASSOCIATION, ADHD, CHILDREN, SCHIZOPHRENIA, GENOTYPE
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT) genes.