Relation between serum IL-4, IL-13 and IFN-gamma levels and recurrence of wheezing episodes in infants with acute bronchiolitis

UZUNER N., Gurcu O., Olmez D., Babayigit A., İŞLEKEL G. H., Karaman O., ...More

PEDIATRIC ALLERGY AND IMMUNOLOGY, vol.19, no.7, pp.648-651, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 7
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1399-3038.2007.00694.x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.648-651
  • Keywords: recurrent wheezing, acute bronchiolitis, interleukin-4, interleukin-13, gamma-interferon, RESPIRATORY-SYNCYTIAL-VIRUS, EOSINOPHIL CATIONIC PROTEIN, REACTIVE AIRWAY DISEASE, ASTHMA, AGE, INFECTION, CYTOKINES, LIFE
  • Dokuz Eylül University Affiliated: Yes


Lower respiratory tract infections are the most important factors among various causes which trigger wheezing in the first year of life. The factors associated with episodic wheezing in children with acute bronchiolitis are still subjects of research. Infections, environmental factors, immunologic mechanisms are sorted as etiologic risk factors of episodic wheezing. We aimed to investigate the relationship between serum interleukin (IL)-4, IL-13 and gamma-interferon (IFN-gamma) levels and recurrence of wheezing episodes in infants with acute bronchiolitis. One hundred twenty infants between 3 and 36 months with acute bronchiolitis enrolled in the study. Personal histories, clinical and laboratory data of infants were recorded. The patients were followed for a year. Venous blood samples were obtained to determine serum IL-4, IL-13, and IFN-gamma levels during acute bronchiolitis episode. The number of wheezing episodes was significantly higher in infants with a positive family history of allergy. A statistically significant correlation was determined between serum IL-13 levels of infants and number of wheezing episodes. High serum IL-13 levels and a positive history of allergy may have important roles in the recurrence of acute bronchiolitis.