Poor clinical course in a child with myelodysplastic syndrome and del(13)(q14q22)

Oren, HALE; Yuksel, E; Yilmaz, E; Turker, M; Demircioglu, F; Irken, G

doi:10.1016/j.cancergencyto.2005.04.008

Poor clinical course in a child with myelodysplastic syndrome and del(13)(q14q22)

Atıf İçin Kopyala

Oren H., Yuksel E., Yilmaz E., Turker M., Demircioglu F., Irken G.

CANCER GENETICS AND CYTOGENETICS, cilt.163, sa.1, ss.74-76, 2005 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 163 Sayı: 1
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.cancergencyto.2005.04.008
Dergi Adı: CANCER GENETICS AND CYTOGENETICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
Sayfa Sayıları: ss.74-76
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Myelodysplastic syndromes (MDS) are rare in children, representing 3% or less of all hematopoietic malignancies. Cytogenetic abnormalities, such as -7/7q-, +8, and +21 have been reported in 55-80% of children with MDS. Cytogenetic studies have an important impact on diagnosis, treatment selection, and monitoring therapeutic protocols when combined with morphologic data. We report on a pediatric case of MDS with the presence of the rare clonal abnormality del(13)(q14q22) which underwent a malignant transformation to leukemia and ran a very poor clinical course. (c) 2005 Elsevier Inc. All rights reserved.