Poor clinical course in a child with myelodysplastic syndrome and del(13)(q14q22)

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Oren H., Yuksel E., Yilmaz E., Turker M., Demircioglu F., Irken G.

CANCER GENETICS AND CYTOGENETICS, vol.163, no.1, pp.74-76, 2005 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 163 Issue: 1
• Publication Date: 2005
• Doi Number: 10.1016/j.cancergencyto.2005.04.008
• Journal Name: CANCER GENETICS AND CYTOGENETICS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
• Page Numbers: pp.74-76
• Dokuz Eylül University Affiliated: Yes

Abstract

Myelodysplastic syndromes (MDS) are rare in children, representing 3% or less of all hematopoietic malignancies. Cytogenetic abnormalities, such as -7/7q-, +8, and +21 have been reported in 55-80% of children with MDS. Cytogenetic studies have an important impact on diagnosis, treatment selection, and monitoring therapeutic protocols when combined with morphologic data. We report on a pediatric case of MDS with the presence of the rare clonal abnormality del(13)(q14q22) which underwent a malignant transformation to leukemia and ran a very poor clinical course. (c) 2005 Elsevier Inc. All rights reserved.