The Role of the Basal Core Promoter (BCP) and Precore Codon 28 Mutations in the Treatment Response to the Pegylated Interferon

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Kose Ş., Senger S. S., Cavdar G., Adar P.

VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL, cilt.20, sa.1, ss.19-22, 2014 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.4274/vhd.74946
  • Dergi Adı: VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.19-22
  • Anahtar Kelimeler: Hepatitis B, pegylated interferon, precore mutations, HEPATITIS-B-VIRUS, E-ANTIGEN, LAMIVUDINE, MUTANTS, REGION, PEGINTERFERON-ALPHA-2A, COMBINATION, MANAGEMENT, INFECTION, GENOTYPES
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objective: Pegylated interferon has an important place in chronic hepatitis treatment and there are many factors affecting treatment response. Among these factors, studies on viral genomic mutations increase recently. In this study we aimed to determine the effects of precore and basal core promoter (BCP) mutations on the response to peg-interferon treatment treatment in patients received interferon treatment with the diagnosis of chronic hepatitis B.