EVALUATION OF TUMOR BURDEN RESPONSE TO SINGLE-CYCLE OF Lu-177 PSMA TREATMENT WITH WHOLE BODY SCINTIGRAPHIC PLANAR IMAGES IN PROSTATE CANCER PATIENTS
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.7, sa.1, ss.471-478, 2023 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 2023
- Doi Numarası: 10.30621/jbachs.1189713
- Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.471-478
- Anahtar Kelimeler: prostate cancer, Lu-177 PSMA, radioligand therapy, scintigraphy
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Purpose: The aim of this study was to evaluate treatment response and survival with post-therapy images in patients who received one cycle of Lu-177 PSMA I&T treatment. Material and Methods: After Lu-177 PSMA I&T treatment was administered to 54 patients, maximum count, pixel count (tumor extent) and sum (total tumor burden) values were calculated with a semiautomatic program. The images after the first treatment were evaluated as basal disease images. Images obtained after the second treatment were considered the response to the first cycle treatment. Results: It was determined that the number of maximum counts (p: 0.015) and tumor extent (p: 0.014) were significantly reduced after one cycle of Lu177 PSMA treatment. No significant change in total tumor burden (p:0.206) was detected. After one treatment cycle the maximum count in 46% of the patients and the total tumor burden in 63% of the patients. The number of pixels (tumor prevalence) in 41% of the patients decreased by >= 25%. Based on the Naive-Bayes method, one-year survival accuracy was 71.6%. Conclusion: With the texture analysis and machine learning of the Lu-177 PSMA post-therapy images, treatment response and survival were determined with high accuracy.