Vitamin D receptor gene polymorphisms and male breast cancer risk in Turkish population

Kizildag S., Gulsu E., Bagci O., Yuksel E., Canda T.

JOURNAL OF BUON, vol.16, no.4, pp.640-645, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2011
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.640-645
  • Keywords: male breast cancer, polymorphisms, RFLP, vitamin D receptor, CARCINOMA, MARKERS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Male breast cancer (MBC) is a rare disease. However; as global populace ages, there is a trend for MBC increase. Although its etiology is still unclear, constitutional, environmental, hormonal (abnormalities in estrogen/androgen balance) and genetic (positive family history, Klinefelter syndrome, mutations in BRCA1 and BRCA2) risk factors are already known. One potential target is the vitamin D receptor (VDR). We have investigated whether polymorphisms in the VDR gene are associated with altered MBC risk in a Turkish population.