Vitamin D receptor gene polymorphisms and male breast cancer risk in Turkish population

Kizildag S., Gulsu E., Bagci O., Yuksel E., Canda T.

JOURNAL OF BUON, cilt.16, sa.4, ss.640-645, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2011
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.640-645
  • Anahtar Kelimeler: male breast cancer, polymorphisms, RFLP, vitamin D receptor, CARCINOMA, MARKERS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Male breast cancer (MBC) is a rare disease. However; as global populace ages, there is a trend for MBC increase. Although its etiology is still unclear, constitutional, environmental, hormonal (abnormalities in estrogen/androgen balance) and genetic (positive family history, Klinefelter syndrome, mutations in BRCA1 and BRCA2) risk factors are already known. One potential target is the vitamin D receptor (VDR). We have investigated whether polymorphisms in the VDR gene are associated with altered MBC risk in a Turkish population.