Microsatellite instability is a rare phenomenon in transition from chronic to blastic phase chronic myeloid leukemia


SERCAN H. O., Sercan Z., KIZILDAĞ S., Sakizli M.

Turkish Journal of Cancer, vol.31, no.2, pp.63-71, 2001 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2001
  • Journal Name: Turkish Journal of Cancer
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.63-71
  • Keywords: Blastic transformation, Chronic phase, CML, Microsatellite instability
  • Dokuz Eylül University Affiliated: Yes

Abstract

Little is understood about the basic biological mechanisms that underlie the reasons for acute transformation in chronic myeloid leukemia (CML). Previously published reports on the potential role of microsatellite instability (MSI) in the transition from chronic to blastic phase CML, are limited in number and contain controversial results. We aimed to analyse DNA of chronic phase and blastic phase archive material of 13 CML patients for genomic instability identified by the presence of MSI using D1S430, D2S123, D3S1611, D11S29, D14S65, D17S520, BAT 40 markers, the dinucleotide repeat located in ABL, and the trinucleotide repeat located in BCR. Only two out of 13 patients manifest alterations in banding patterns in two or more loci examined and presented MSI (15%). We conclude that MSI may be a late occurring but rare event in CML evolution, and in itself is far from explaining the general instability observed in CML.