Is the expression of placental epithelial and lymphoid markers associated with the perinatal outcomes in preeclampsia?

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BAYRAMOĞLU Z., Ozler S.

GINEKOLOGIA POLSKA, vol.94, no.11, pp.929-938, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94 Issue: 11
  • Publication Date: 2023
  • Doi Number: 10.5603/gp.a2023.0027
  • Journal Name: GINEKOLOGIA POLSKA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, Gender Studies Database, Directory of Open Access Journals
  • Page Numbers: pp.929-938
  • Dokuz Eylül University Affiliated: No

Abstract

Objectives: This study aimed to investigate the association of the epithelial and lymphoid immune markers with the adverse perinatal conditions such as early-onset preeclampsia (EOPE), fetal growth restriction (FGR) and intrauterine fetal death (IUFD) in preeclampsia in the placentae of preeclamptic patients. Material and methods: A total of 60 pregnant patients were included in this study. The immunohistochemistry method was used to determine the expression levels of CD4, CD8, CD4 / CD8, CD68, P53, MDM2, CK18, CK19, E-cadherin, and [1-catenin. Results: In our study, the increase in E-cadherin expression in the preeclamptic fetal-maternal placental region was associated with EOPE and FGR development preeclampsia and the decrease in the expression of CD4 and CD8, which are involved in the local immunomodulation, was associated with IUFD. Conclusions: Our data reveal that the increase in the expression of CK18, CK19, E-cadherin, and [1-catenin and the decrease in CD4 and CD8 play a role in the pathogenesis of preeclampsia.