Mild-intensity exercise triggers VEGF in the digestive tract via both hypoxic and nonhypoxic mechanisms

Hosgorler F., KIZILDAĞ S., Koc B., YÜKSEL O., Kirik A. B. T., Ilgin R., ...More

Brazilian Archives of Biology and Technology, vol.63, 2020 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 63
  • Publication Date: 2020
  • Doi Number: 10.1590/1678-4324-2020180059
  • Journal Name: Brazilian Archives of Biology and Technology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: Exercise, Gastrointestinal, Hypoxia, VEGF
  • Dokuz Eylül University Affiliated: Yes


© 2020 the authors.Hypoxia occurs in the splanchnic region during exercise associated with sympathetic activity. In the elderly, vascular insufficiency and low vascular endothelial growth factor (VEGF) expression are observed. Compared to young people, sympathetic signals of older individuals are blunted and more resistant to splanchnic blood flow alterations during exercise. VEGF induces vasodilation responses and hence may retain blood in the splanchnic vascular bed. We hypothesized that regular mild-intensity exercise triggers weak VEGF expression in the digestive tract of the elderly. The effects of exercise on the levels of VEGF, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) in the stomach, jejunum, ileum and colon tissues were evaluated. With exercise, the VEGF levels in the stomach and colon increased. Although the SOD, GPx, and MDA levels decreased in the stomach, they increased in the colon. T-AOC increased in the stomach and there was no change in the jejunum, ileum and colon. The hypoperfusion during exercise was not equal in all regions of the gastrointestinal tract in the aged subjects. Hypoxia and other exercise-related mechanisms could have led to this VEGF induction. The stomach, jejunum, and ileum might have developed resistance to ischemia. The induction of VEGF may be beneficial in aging-associated impaired gastrointestinal homeostasis and neovascularization.