Papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence results

Gunes, A.; İLKNUR, TURNA; Pabuccuoglu, U.; Lebe, B.; Altiner, D.

doi:10.1111/j.1365-2230.2007.02385.x

Papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence results

Copy For Citation

Gunes A. T., İLKNUR T., Pabuccuoglu U., Lebe B., Altiner D. D.

CLINICAL AND EXPERIMENTAL DERMATOLOGY, vol.32, no.3, pp.301-303, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 32 Issue: 3
Publication Date: 2007
Doi Number: 10.1111/j.1365-2230.2007.02385.x
Journal Name: CLINICAL AND EXPERIMENTAL DERMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.301-303
Dokuz Eylül University Affiliated: No

Abstract

Acantholytic dyskeratosis is a distinct histological pattern characterized by hyperkeratotic and parakeratotic epidermis with intraepidermal clefts harbouring acantholytic and dyskeratotic keratinocytes. This histopathological pattern is uncommon in dermatoses of the anogenital region. We report a 30-year-old woman who had numerous smooth whitish papules on the labia majora, perineum and perianal region, which coalesced into plaques in some areas. Microscopically, the lesions showed prominent suprabasal and intraspinous acantholysis with dyskeratotic keratinocytes. Direct immunofluorescence examination revealed intercellular Ig G and C-3 within the epidermis. We were unable to find a similar case of papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence findings reported in the literature, thus in this report, the clinicopathological features of a unique case are presented.