MicroRNAs as regulators of apoptosis mechanisms in cancer

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Pileczki V., Cojocneanu-Petric R., Maralani M., Neagoe I. B., Sandulescu R.

Clujul Medical, cilt.89, sa.1, ss.50-55, 2016 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.15386/cjmed-512
  • Dergi Adı: Clujul Medical
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.50-55
  • Anahtar Kelimeler: Apoptosis, Cancer, Cancer therapy, MicroRNAs
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

MicroRNAs or miRNAs are small non-coding RNAs that regulate gene expression. Their discovery has brought new knowledge in biological processes of cancer. Involvement of miRNAs in cancer development includes several major pathways from cell transformation to tumor cell development, metastasis and resistance to treatment. The first part of this review discusses miRNAs function in the intrinsic and extrinsic pathways of apoptosis. Due to the fact that many miRNAs that regulate apoptosis have been shown to play a major role in tumor cell resistance to treatment, in the second part of the review we aim at discussing miRNAs potential in becoming curative molecules.