Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation

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Akcali A., Bostanci N., Ozcaka O., Ozturk-Ceyhan B., Gumus P., Tervahartiala T., ...More

INNATE IMMUNITY, vol.21, no.6, pp.619-625, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.1177/1753425915572172
  • Journal Name: INNATE IMMUNITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.619-625
  • Keywords: Gingivitis, metalloproteinase-8, polycystic ovary syndrome, saliva, serum, HUMAN NEUTROPHIL, WOMEN, MATRIX-METALLOPROTEINASE-9, DIAGNOSTICS, ACTIVATION, BIOMARKERS, PHYSIOLOGY, INSULIN, DISEASE, OBESITY
  • Dokuz Eylül University Affiliated: No

Abstract

This study aimed to investigate the levels of matrix metalloproteinase-8 (MMP-8) and tissue inhibitors of MMP-1 (TIMP-1) in saliva and serum samples of women with polycystic ovary syndrome (PCOS; n=80) and matched systemically healthy controls (n=45), with varying degrees of gingival inflammation. Salivary levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly elevated in women with PCOS, who also exhibited more gingivitis than systemically healthy women. No major changes were observed in salivary TIMP-1 levels with regard to PCOS. Serum levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly higher in women with PCOS, irrespective of the presence of gingivitis, while there were no differences in TIMP-1 levels. A positive correlation was indicated between probing depth, bleeding on probing, plaque index and salivary or serum MMP-8 levels or MMP-8/TIMP-1 ratio in the case of PCOS, while a negative such correlation was revealed for TIMP-1 in systemically healthy women. Increased levels of MMP-8 in saliva and serum seem to be more pronounced in women with PCOS, and potentiated in the presence of gingival inflammation. Alterations in MMP/TIMP system triggered by local and systemic inflammation may be implicated in the pathogenesis of PCOS, or the deterioration of its clinical presentation.