Fresh homografts obtained through a national organ-sharing programme for repair of congenital heart disease.


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Metin S., Ugurlu B., Oto O., Sariosmanoglu O., Hazan E., Unal N., ...More

The Journal of international medical research, vol.33, no.1, pp.123-31, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1177/147323000503300114
  • Journal Name: The Journal of international medical research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.123-31
  • Keywords: homograft, transplantation, congenital, cardiac, OUTFLOW TRACT RECONSTRUCTION, PULMONARY-ARTERY CONDUITS, AORTIC-VALVE REPLACEMENT, CRYOPRESERVED ALLOGRAFT, EXPERIENCE, FAILURE, XENOGRAFTS, VENTRICLE, OPERATION, CHILDREN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Homografts have been used in congenital cardiac surgery for over 30 years. We utilized the resources of a national organ-sharing programme to obtain fresh homografts and report their use in correcting cardiac pathologies in 20 children between March 2001 and May 2003. In 16 patients, a valved conduit was used to form a connection between the pulmonary ventricle and the pulmonary artery. In three patients, a non-valved aortic conduit was used to form an extra-cardiac Fontan circulation and in one patient, non-valved pulmonary and aortic conduits were used to repair an infected aortic aneurysm. Three patients died following surgery. Survivors were followed up using echocardiography between 2 and 24 months post-surgery. Results demonstrate that, with the help of a national organ-sharing programme, the use of fresh homograft conduits is feasible in a paediatric patient population with reasonable waiting times.