Structural dysconnectivity in offspring of individuals with bipolar disorder: The effect of co-existing clinical-high-risk for bipolar disorder

BORA İ. E., Can G., Zorlu N., Ulas G., Inal N., Ozerdem A.

JOURNAL OF AFFECTIVE DISORDERS, vol.281, pp.109-116, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 281
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jad.2020.11.122
  • Journal Name: JOURNAL OF AFFECTIVE DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, AgeLine, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.109-116
  • Keywords: Bipolar disorder, High-risk, offspring, MRI, Connectivity, DTI, WHITE-MATTER INTEGRITY, BRAIN NETWORK ANALYSIS, RICH-CLUB, YOUNG-PEOPLE, METAANALYSIS, SCHIZOPHRENIA, CONNECTIVITY, CONNECTOME, HERITABILITY, INTEGRATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Bipolar disorder (BD) might be associated in disturbances in brain networks. However, little is known about the abnormalities in structural brain connectivity which might be related to vulnerability to BD and predictive of the emergence of manic symptoms. No previous study has investigated the effect of subthreshold syndromes on structural dysconnectivity in offspring of parents with BD (BDoff).