Effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on endothelial dysfunction, lipid peroxidation, and hepatocyte morphology in rats with sepsis-induced liver damage

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Kara E., Var A., Vatansever S., Cilaker S., Kaya Y., Coskun T.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.65, no.3, pp.278-291, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/s0011-393x(04)80087-0
  • Journal Name: CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.278-291
  • Keywords: lipid peroxidation, nitric oxide, selective COX-2 inhibitor, experimental sepsis, NITRIC-OXIDE SYNTHASE, SEPTIC SHOCK, FREE-RADICALS, ENDOTOXIC-SHOCK, TISSUE-INJURY, SURVIVAL, MICE, ALPHA, PERITONITIS, MODULATION
  • Dokuz Eylül University Affiliated: No

Abstract

Background: Sepsis remains a difficult problem for clinicians, with its systemic effects and high morbidity and mortality rates. The roles of oxidative stress, endothelial dysfunction, and lipid peroxidation in sepsis-induced organ damage are being investigated.