Synthesis, Characterization, and Enzymatic Degradation of Chitosan/PEG Hydrogel Films

ALTINIŞIK TAĞAÇ A., YURDAKOÇ M. K.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.122, no.3, pp.1556-1563, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 122 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1002/app.34278
  • Journal Name: JOURNAL OF APPLIED POLYMER SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1556-1563
  • Keywords: chitosan, hydrogel, PEG, temperature sensitive, pH sensitive, enzymatic degradation, CONTROLLED-RELEASE, IN-VITRO, CHITIN, PEG, CHEMISTRY, DESIGN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Poly(ethyleneglycol) (PEG)/tartaric acid (TA)-crosslinked chitosan hydrogel (CPT) films were prepared, and the formation of the PEG/TA-crosslinked structure was confirmed by Fourier transformed infrared (FTIR), nuclear magnetic resonance (NMR), and scanning electron microscope (SEM) measurements. The thermal properties of the crosslinked films were also determined with thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC) analysis. The swelling properties of the films were investigated at different temperature and pH values. It was found that the swelling ratio increased with the decrease of pH value of the surrounding buffer solutions, amount of PEG, and with the increase of temperature. Swelling behavior of the PEG/TA-crosslinked chitosan hydrogel films depended on pH and reversible with the temperature. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 1556-1563, 2011