Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism
Archives of Physiology and Biochemistry, cilt.123, sa.1, ss.9-15, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 123 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.1080/13813455.2016.1211709
- Dergi Adı: Archives of Physiology and Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.9-15
- Anahtar Kelimeler: Apelin, reproductive functions, food intake, body weight, uncoupling proteins
- Dokuz Eylül Üniversitesi Adresli: Hayır
Özet
Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague–Dawley rats were used (four groups; n = 10). Apelin-13 at three different dosages (1, 5 and 50 μg/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p < 0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p < 0.05), but caused significant decreases in high-density lipoprotein levels (p < 0.05). Serum glucose and triglyceride levels were not significantly altered by apelin-13 administration. Significant decreases in both uncoupling protein (UCP)-1 levels in the white and brown adipose tissues and UCP-3 levels in the biceps muscle (p < 0.05) were noted. The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.