Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism

Aksoy D. Y., Gedik A., Cinar N., Soylemezoglu F., BERKER M., GÜRLEK Ö. A.

JOURNAL OF RESEARCH IN MEDICAL SCIENCES, vol.18, no.11, pp.1008-1010, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 11
  • Publication Date: 2013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1008-1010
  • Keywords: Central hyperthyroidism, thyrotropinoma (TSHoma), TSH-secreting adenoma, toxic goiter, toxic nodular goiter, SECRETING PITUITARY-ADENOMAS, STIMULATING-HORMONE, RESISTANCE, FEATURES, PATIENT, TUMORS
  • Dokuz Eylül University Affiliated: Yes


Thyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presentation of the disease becomes unusual when co-secretion of other hormones with thyrotropin or concomitant thyroid parenchymal pathology exist. We present the case of a 63-year-old female patient with thyrotropinoma co-secreting growth hormone and multinodular goiter. She developed hyperthyroidism first due to thyrotropinoma and later due to a toxic nodule. Herein, we discuss the diagnostic and therapeutic challenges of hyperthyroidism with atypical presentation.