The prognostic importance of double-expressor subgroup and AID, UNG and mismatch repair protein expressions in diffuse large B-cell lymphomas

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Toper M. H., BOZKURT S., ELİBOL T., Tuglular T.

MARMARA MEDICAL JOURNAL, vol.33, no.2, pp.83-89, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.5472/marumj.741651
  • Journal Name: MARMARA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.83-89
  • Keywords: Diffuse large B-cell lymphoma, Double-expressor lymphoma, MYC, BCL2, AID, Mismatch repair proteins, INDUCED CYTIDINE DEAMINASE, RITUXIMAB PLUS CYCLOPHOSPHAMIDE, IMMUNOHISTOCHEMICAL BIOMARKERS, MYC REARRANGEMENT, P53 EXPRESSION, C-MYC, SURVIVAL, GENE, BCL2, CLASSIFICATION
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: The cases of diffuse large B-cell lymphoma, (DLBCL not otherwise specified (NOS)) which immunohistochemically exhibit MYC and BCL2 expressions arc defined as double-expressor lymphomas (DELs). This study aimed to assess the prognostic impact of DEL and the expressions of other proteins that may have role in tumorogenesis.