Neurocognitive heterogeneity in young offspring of patients with bipolar disorder: The effect of putative clinical stages

BORA İ. E., Can G., Ildiz A., Ulas G., HIDIROĞLU ONGUN C., Inal N. E., ...More

JOURNAL OF AFFECTIVE DISORDERS, vol.257, pp.130-135, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 257
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jad.2019.07.015
  • Journal Name: JOURNAL OF AFFECTIVE DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.130-135
  • Keywords: Bipolar disorder, Cognition, Offspring, Relatives, Subgroups, COGNITIVE IMPAIRMENT, FUNCTIONAL OUTCOMES, EUTHYMIC PATIENTS, MOOD DISORDERS, SCHIZOPHRENIA, PRODROME, MANIA, METAANALYSIS, IMPULSIVITY, DYSFUNCTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Bipolar disorder (BD) is associated with significant cognitive heterogeneity. In recent years, a number of studies have investigated cognitive subgroups in BD using data-driven methods and found that BD includes several subgroups including a severely impaired and a neurocognitively intact cluster. Studies in offspring of BD (BDoff) are particularly important to establish the timing of emergence of cognitive subgroups but studies investigating cognitive heterogeneity in BDoff are lacking. Our aim was to investigate cognitive heterogeneity in BDoff and the relationship between cognitive heterogeneity and putative clinical stages of BD.