Akademik Veri Yönetim Sistemi
JOURNAL OF MEDICAL VIROLOGY, cilt.89, sa.11, ss.1952-1957, 2017 (SCI-Expanded)
In this study, we evaluated the relationship of hepatitis B virus (HBV) DNA levels with liver histology and various other liver related parameters and the predictors of histologically active liver disease requiring treatment (Histological activity 6 and/or grade 2 by Ishak's classification) in patients with HBeAg negative chronic HBV infection. Demographic data, laboratory findings and liver histology findings of patients with no clinical cirrhosis who underwent liver biopsy considering HBeAg negative chronic hepatitis (HBV DNA >2000IU/mL) were analyzed. Two hundred and fifteen patients were included in this retrospective study. Treatment indication by histologic findings were 85.7%, 61.2%, and 64%, respectively, in group 1 (HBV DNA 200000), group 2 (HBV DNA 20000-200000), and group 3 (HBV DNA 2000-20000IU/mL) (P=0.001). Group 1 was different from other groups in terms of aspartate aminotransferase (AST), alanine aminotransferase (ALT), fibrosis stage, necroinflammatory activity, and platelet count. Multiple logistic regression analysis revealed that, advanced age (cut-off was 46 years), higher than normal AST and HBV DNA 200000IU/mL (compared to group 3) were found to be the predictors of histologically active disease with treatment indication. Conclusively, most of the patients with HBV DNA 200000IU/mL showed treatment requiring liver injury, but also a significant portion of the patients with HBV DNA 2000-200000IU/mL carried an indication for treatment. Although age (>46 years) and AST (>40IU/L) can be helpful to predict treatment requirement in patients with HBV DNA 2000-200000IU/mL, sufficient effort should be made to find out the significant liver damage.