Comparison of health-related quality of life and exercise capacity according to stages in patients with non-small cell lung cancer Küçük hücreli dışı akciǧer kanseri olan hastalarda evrelere göre yaşam kalitesi ve egzersiz kapasitesinin karşılaştırılması

Yilmaz E., ÖZALEVLİ S., Ersöz H., Yeǧin A., Önen A., Akkoçlu A.

Tuberkuloz ve Toraks, vol.61, no.2, pp.131-139, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.5578/tt.5396
  • Journal Name: Tuberkuloz ve Toraks
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.131-139
  • Keywords: Exercise capacity, Health-related quality of life, Non-small cell lung cancer
  • Dokuz Eylül University Affiliated: Yes


Introduction: The aim of this study is to compare the exercise capacity and health-related quality of life parameters according to stages of patients with non-small cell lung cancer (NSCLC). Materials and Methods: Fifty-two patients (who are able to ambulate independently) with stage I-II (group early-stage, n= 17) and stage IIIA-IV NSCLC (group advanced-stage, n= 35) were included. Exercise capacity (six minute walking test), strength of the peripheral muscle (Back and Leg Dynamometer), performance status (Karnofsky performance status scale), health-related quality of life- HRQOL (European Organization for Research and Treatment of Cancer Quality of life measure and Short Form-36 Health Survey), depression and anxiety (Hospital Anxiety and Depression Scale) were evaluated. Results: No difference was found in age, body mass index, respiratory symptoms and the distribution of disease cell types between two groups (p> 0.05). In advanced-stage group, pulmonary function test values, peripheral muscle strength, walking distance and health-related quality of life scores especially the categories of functional capacity and pain were established significantly lower compared to early-stage group (p≤ 0.05). Depression and anxiety levels were confirmed to be similar between groups (p> 0.05). Conclusion: The exercise capacity of patients with advanced-stage NSCLC is lower due to reduced pulmonary functions and peripheral muscle strength compared to patients with early-stage NSCLC. Therefore, we can conclude that reduced exercise capacity negatively impacts functional categories of health related quality of life of patients with advanced-stage NSCLC.