Effect of magnesium sulfate on renal ischemia-reperfusion injury in streptozotocin-induced diabetic rats

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Akan M., Özbilgin Ş., Boztaş N., Çelik A., Ozkardesler S., Ergur B. U., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.20, sa.8, ss.1642-1655, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 8
  • Basım Tarihi: 2016
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1642-1655
  • Anahtar Kelimeler: Acute kidney injury, Experimental diabetes mellitus, Reperfusion injury, Magnesium sulfate, LUNG INJURY, SPINAL-CORD, KIDNEY, DEXMEDETOMIDINE, PATHOPHYSIOLOGY, NEUROPROTECTION, PRETREATMENT, ACTIVATION, EXPRESSION, PROTECTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Ischemia/reperfusion (I/R) injury is a major cause of acute organ dysfunction and I/R related acute renal failure is a common clinical problem. Diabetes mellitus is defined as a risk factor for the development of acute renal injury as diabetic nephropathy compromises the renal tolerance to ischemia. The aim of this study was to investigate the protective effect of magnesium sulfate in a diabetic rat renal I/R injury model.