Effect of magnesium sulfate on renal ischemia-reperfusion injury in streptozotocin-induced diabetic rats

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Akan M., Özbilgin Ş., Boztaş N., Çelik A., Ozkardesler S., Ergur B. U., ...More

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.20, no.8, pp.1642-1655, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 8
  • Publication Date: 2016
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1642-1655
  • Keywords: Acute kidney injury, Experimental diabetes mellitus, Reperfusion injury, Magnesium sulfate, LUNG INJURY, SPINAL-CORD, KIDNEY, DEXMEDETOMIDINE, PATHOPHYSIOLOGY, NEUROPROTECTION, PRETREATMENT, ACTIVATION, EXPRESSION, PROTECTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVE: Ischemia/reperfusion (I/R) injury is a major cause of acute organ dysfunction and I/R related acute renal failure is a common clinical problem. Diabetes mellitus is defined as a risk factor for the development of acute renal injury as diabetic nephropathy compromises the renal tolerance to ischemia. The aim of this study was to investigate the protective effect of magnesium sulfate in a diabetic rat renal I/R injury model.