Metreleptin replacement treatment improves quality of life and psychological well-being in congenital generalized lipodystrophy

YILDIRIM ŞİMŞİR I., ŞARER YÜREKLİ B. P., Polat I., Saygili F., AKINCI B.

NATIONAL MEDICAL JOURNAL OF INDIA, cilt.33, sa.5, ss.278-280, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4103/0970-258x.317476
  • Dergi Adı: NATIONAL MEDICAL JOURNAL OF INDIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.278-280
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The near total lack of subcutaneous fat in congenital generalized lipodystrophy (CGL) leads to the accumulation of fat in ectopic organs and severe insulin resistance, which are associated with serious metabolic abnormalities. Cosmetic aspects of the disease are likely to affect the quality of life (QoL) and physiological well-being in these individuals. Metreleptin, recombinant human leptin, replacement treatment has been shown to have benefits in treating the metabolic abnormalities of CGL. In a patient with CGL caused by a homozygous AGPAT2 pathogenic variant, we examined QoL and mood alterations (depression and anxiety) caused by this chronic disease. Metreleptin replacement treatment led to dramatic metabolic improvement in our patient. It was also was associated with improvements in QoL, depression and anxiety scores. We suggest that there is need for studies to document the benefit of metreleptin replacement treatment on QoL and physiological well-being in patients with CGL.