Role of thrombin activatable fibrinolysis inhibitor in endocrine and cardiovascular disorders


AKINCI B., Yesil S.

Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, cilt.2, sa.1, ss.57-61, 2008 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 2 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2174/187221408783421327
  • Dergi Adı: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Aerospace Database, Biotechnology Research Abstracts, Communication Abstracts, EMBASE, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.57-61
  • Anahtar Kelimeler: Coronary artery disease, Endocrine, Oestrogen, Stroke, Thrombin activatable fibrinolysis inhibitor, Thyroid
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Thrombin activatable fibrinolysis inhibitor (TAFI) is a zymogene that potently inhibits fibrinolysis. It is synthesized by the liver and has an inhibitor role in fibrinolysis through the removal of the carboxy-terminal lysine and arginine residues from partially degraded fibrin polymers. Besides, TAFI has a suppressor effect on conversion of inactive plasminogen to plasmin. Alterations in TAFI pathway have been reported in many conditions. Few data are present in the literature regarding the relationship between TAFI and endocrine disorders. The results from few studies in patients with cardiovascular disease are conflicting. Understanding the role of TAFI in the pathogenesis of endocrine and cardiovascular disorders may hold promise for improving management of these diseases. This paper includes a review of the studies and patents concerned with TAFI pathway and endocrine and cardiovascular problems. © 2008 Bentham Science Publishers Ltd.