Role of thrombin activatable fibrinolysis inhibitor in endocrine and cardiovascular disorders

AKINCI B., Yesil S.

Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, vol.2, no.1, pp.57-61, 2008 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 2 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.2174/187221408783421327
  • Journal Name: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Aerospace Database, Biotechnology Research Abstracts, Communication Abstracts, EMBASE, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.57-61
  • Keywords: Coronary artery disease, Endocrine, Oestrogen, Stroke, Thrombin activatable fibrinolysis inhibitor, Thyroid
  • Dokuz Eylül University Affiliated: Yes

Abstract

Thrombin activatable fibrinolysis inhibitor (TAFI) is a zymogene that potently inhibits fibrinolysis. It is synthesized by the liver and has an inhibitor role in fibrinolysis through the removal of the carboxy-terminal lysine and arginine residues from partially degraded fibrin polymers. Besides, TAFI has a suppressor effect on conversion of inactive plasminogen to plasmin. Alterations in TAFI pathway have been reported in many conditions. Few data are present in the literature regarding the relationship between TAFI and endocrine disorders. The results from few studies in patients with cardiovascular disease are conflicting. Understanding the role of TAFI in the pathogenesis of endocrine and cardiovascular disorders may hold promise for improving management of these diseases. This paper includes a review of the studies and patents concerned with TAFI pathway and endocrine and cardiovascular problems. © 2008 Bentham Science Publishers Ltd.