Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo H-1 MRS study

Frey B. N., Stanley J. A., Nery F. G., Monkul E. S., Nicoletti M. A., Chen H., ...More

BIPOLAR DISORDERS, vol.9, pp.119-127, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1399-5618.2007.00454.x
  • Journal Name: BIPOLAR DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-127
  • Keywords: bipolar disorder, brain imaging dorsolateral, prefrontal cortex, magnetic resonance spectroscopy, MAGNETIC-RESONANCE-SPECTROSCOPY, N-ACETYL-ASPARTATE, BRAIN PHOSPHORUS-METABOLISM, MITOCHONDRIAL DYSFUNCTION, ACUTE MANIA, NEUROPSYCHIATRIC DISORDERS, CREATINE-KINASE, FRONTAL LOBES, RATING-SCALE, LITHIUM
  • Dokuz Eylül University Affiliated: No

Abstract

Objectives: While the pathophysiology of bipolar disorder (BD) remains to be elucidated, postmortem and neuroimaging studies have suggested that abnormalities in the dorsolateral prefrontal cortex (DLPFC) are implicated. We compared the levels of specific brain chemicals of interest measured with proton magnetic resonance spectroscopy (H-1 MRS) in medication-free BD subjects and age- and gender-matched healthy controls. We hypothesized that BD subjects would present abnormal cellular metabolism within the DLPFC, as reflected by lower N-acetyl-aspartate (NAA) and creatine + phosphocreatine (Cr + PCr).