A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study

ÜÇÜNCÜ M., Canturk C., Karakus E., Zeybek H., BOZKAYA U., Soydas E., ...More

ORGANIC & BIOMOLECULAR CHEMISTRY, vol.14, no.31, pp.7490-7494, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 31
  • Publication Date: 2016
  • Doi Number: 10.1039/c6ob01099g
  • Journal Name: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
  • Page Numbers: pp.7490-7494
  • Dokuz Eylül University Affiliated: No

Abstract

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straight-forward synthetic route has been developed for a range of pyrazole fused gamma-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of gamma-pyranopyrazole is furthermore fully supported by experimental and computational studies.