Nutrition and disease-related entropy generation in cancer


Öngel M. E., Yildiz C., Yilmaz B., Özilgen M.

International Journal of Exergy, cilt.34, sa.4, ss.411-423, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1504/ijex.2021.114091
  • Dergi Adı: International Journal of Exergy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.411-423
  • Anahtar Kelimeler: Cancer patients, Disease-related entropy generation, Entropic-age, Nutrition-related entropy generation, Tissue-scavenging
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The lifespan entropy generation limit concept suggests that living beings die after generating a definite amount of lifespan entropy, since their bodies cannot tolerate accumulating more damage. A healthy person, who has a lifespan of 78.6 years may generate 11,404 kJ/kg K of nutrition-related lifespan entropy. If that person should be diagnosed with cancer at the age of 40, he/she would have already generated 5,803 kJ/kg K of nutrition-related entropy and may generate 5,593 kJ/kg K of more entropy until dying. After the onset of the disease, approximately 97 kJ/kg K of entropy may be generated via nutrition-related metabolic activity in five years. In lung cancer, disease-related entropy generation is 191 fold of that of the diet-related entropy generation and this is nine folds in skin cancer. This study points out that a very high fraction of the lifespan entropy generated by the cancer patients is fueled not by diet, but by tissue-scavenging, slowing down the scavenging-related chemical activity may actually increase the lifespan of the patients.