Nutrition and disease-related entropy generation in cancer


Öngel M. E., Yildiz C., Yilmaz B., Özilgen M.

International Journal of Exergy, vol.34, no.4, pp.411-423, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1504/ijex.2021.114091
  • Journal Name: International Journal of Exergy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.411-423
  • Keywords: Cancer patients, Disease-related entropy generation, Entropic-age, Nutrition-related entropy generation, Tissue-scavenging
  • Dokuz Eylül University Affiliated: No

Abstract

The lifespan entropy generation limit concept suggests that living beings die after generating a definite amount of lifespan entropy, since their bodies cannot tolerate accumulating more damage. A healthy person, who has a lifespan of 78.6 years may generate 11,404 kJ/kg K of nutrition-related lifespan entropy. If that person should be diagnosed with cancer at the age of 40, he/she would have already generated 5,803 kJ/kg K of nutrition-related entropy and may generate 5,593 kJ/kg K of more entropy until dying. After the onset of the disease, approximately 97 kJ/kg K of entropy may be generated via nutrition-related metabolic activity in five years. In lung cancer, disease-related entropy generation is 191 fold of that of the diet-related entropy generation and this is nine folds in skin cancer. This study points out that a very high fraction of the lifespan entropy generated by the cancer patients is fueled not by diet, but by tissue-scavenging, slowing down the scavenging-related chemical activity may actually increase the lifespan of the patients.