Levels of interleukin-6 (IL-6) and its soluble (sIL-6R) in familial Mediterranean fever (FMF) patients and their first degree relatives

Oktem S., Yavuzsen T., Sengul B., Akhunlar H., Akar S., Tunca M.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.22, no.4, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 2004
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: familial Mediterranean fever (FMF), IL-6, sIL-6R, FMF carriers, C-REACTIVE PROTEIN, RECEPTOR, INFLAMMATION, INDUCTION, CYTOKINES, DIAGNOSIS, DISEASE, ALPHA, CELLS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective. Familial Mediterranean Fever (FMF) is a hereditary disease characterized by recurrent inflammatory attacks. A subclinical inflammation may persist in periods between the attacks and heterozygotes may have higher than normal levels of acute phase proteins. We investigated the levels of interleukin-6 (IL-6) and its soluble receptor (sIL-6R) in FMF patients and their obligatory carrier relatives.