Parathyroid Allotransplant With a New Technique: A Prospective Clinical Trial
Experimental and Clinical Transplantation, vol.14, no.4, pp.431-435, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 14 Issue: 4
- Publication Date: 2016
- Doi Number: 10.6002/ect.2014.0294
- Journal Name: Experimental and Clinical Transplantation
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.431-435
- Keywords: Parathyroid, Allograft, New technique, Clinical
- Dokuz Eylül University Affiliated: No
Abstract
Objectives: Parathyroid allotransplant is a valuable alternative in treating permanent hypoparathyroidism. However, it is a difficult process that requires several trained staff and advanced laboratory equipment, which makes the costs high. Here, we identify a new parathyroid allotransplant technique. Materials and Methods: After obtaining informed consent from patients, parathyroid cell suspensions obtained from 4 donors who had undergone a subtotal parathyroidectomy owing to chronic renal failure were transplanted in 10 patients with permanent hypoparathyroidism after short-term cell cultivation. Prednisolone were used as immunosuppressant for the first 10 days and discontinued thereafter. Results: Allograft function was observed in 7 patients (70%) at a mean follow-up of 12 months. Daily oral calcium and vitamin D supplementations discontinued totally in 7 patients. No major or minor complication was observed. Conclusions: Our technique is simple, fast, and has a low cost, with a 70% success rate at a mean follow-up of 12 months. It requires few staff, minimal equipment, and short-term immunosuppressant use for maintenance. The technical developments of parathyroid allotransplant, as mentioned in this study, may be important in treating permanent hypoparathyroidism.