Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.30, sa.10, ss.446-453, 2002 (Scopus)
In this study, we aimed to evaluate the effects of intravenous midazolam and propofol infusions on portal vein blood flow velocity, portal output, cross sectional area of portal vein, and hepatic artery blood flow velocity that had been measured with Doppler ultrasonography. We studied 24 Sprague-Dawley rats allocated to three groups. Group P received propofol 2-3 mL/kg/h while Group M midazolam 2-3 mL/kg/h and Group K saline 2-3 ml/kg/h. Mean arterial pressure (MAP) and heart rate (HR) were monitored. Portal vein blood flow velocity (PVBFV), portal output (PO), cross sectional area of portal vein, hepatic artery blood flow velocity (HABFV) and stroke volume (SV) were measured with Doppler ultrasonography. Cardiac output (CO) calculated by equation. Hemodynamic data and arterial blood gas analysis were recorded at the beginning, 5., 15., 30., 60., 120., 240. and 360 minutes of infusion. In the Group P, MAP, HR, CO and SV decreased when compared with baseline values (p<0.05). In group M, MAP decreased significantly (p<0.05). The cross sectional area of portal vein increased in the propofol group (1.27±0.25 α 1.92±0.55) but PVBFV (12.71±0.95 α 12.57±3.04) remained constant because of the increase in the PO (31.85±4.77 α 42.00±17.96). The cross sectional area of portal vein, PVBFV and PO remained unchanged in both midazolam and control groups. HABFV was similar in all three groups. We conclude that propofol has a prominent vasodilatator effect on portal vein region and may be preferred as a sedative agent during invasive interventional radiologic procedures. Besides, midazolam will offer many advantages since it induces minimal changes on portal hemodynamic data and may be used safely.