Does hypokalaemia cause nephropathy? an observational study of renal function in patients with Bartter or Gitelman syndrome

Walsh S. B., Unwin E., Vargas-Poussou R., Houillier P., Unwin R.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, cilt.104, sa.11, ss.939-944, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 104 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1093/qjmed/hcr095
  • Dergi Adı: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.939-944
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Hypokalaemic nephropathy has been described in patients with chronic potassium depletion; it is a condition in which proximal tubular vacuolization and interstitial fibrosis occur, resulting in a decline in glomerular filtration rate (GFR) and, in some cases, renal failure. It has been described in patients with chronic diarrhoea, eating disorders, laxative abuse and primary hyperaldosteronism; also occasionally in Bartter syndrome (BS), in which severe hypokalaemia accompanies significant renal sodium and water losses, though rarely in Gitelman syndrome (GS), in which there is equally severe hypokalaemia, but only modest sodium losses.