Does hypokalaemia cause nephropathy? an observational study of renal function in patients with Bartter or Gitelman syndrome
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, vol.104, no.11, pp.939-944, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 104 Issue: 11
- Publication Date: 2011
- Doi Number: 10.1093/qjmed/hcr095
- Journal Name: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.939-944
- Dokuz Eylül University Affiliated: No
Abstract
Background: Hypokalaemic nephropathy has been described in patients with chronic potassium depletion; it is a condition in which proximal tubular vacuolization and interstitial fibrosis occur, resulting in a decline in glomerular filtration rate (GFR) and, in some cases, renal failure. It has been described in patients with chronic diarrhoea, eating disorders, laxative abuse and primary hyperaldosteronism; also occasionally in Bartter syndrome (BS), in which severe hypokalaemia accompanies significant renal sodium and water losses, though rarely in Gitelman syndrome (GS), in which there is equally severe hypokalaemia, but only modest sodium losses.