New morpholine or triphenylphosphine-liganded palladium(II) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, and anticancer activity

GÖK Y., Özkan G., Kuruçay A., ATEŞ B., AKTAŞ A., Demirci Ö., ...Daha Fazla

Inorganica Chimica Acta, cilt.593, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 593
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.ica.2026.123062
  • Dergi Adı: Inorganica Chimica Acta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex
  • Anahtar Kelimeler: Anticancer activity, Crystal structure, N-heterocyclic carbenes, Palladium
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

A series of morpholine(Morp.)-liganded palladium(II) complexes (1a–c) and triphenylphosphine(PPh3)-liganded palladium(II) complexes (2a–c) bearing 4-fluorobenzyl substituted N-heterocyclic carbene (NHC) were synthesized from NHC-Pd(II)-pyridine and Morp./PPh3 by ligand exchange method. The new complexes were fully characterized using 1H NMR, 13C NMR, 19F NMR, 31P NMR, FTIR spectroscopy and elemental analysis techniques. Furthermore, single crystal X-ray diffraction was used to elucidate the structures of complexes 1a and 2b. The anticancer activities of the new complexes against MCF-7 (Human Breast Cancer) cell line were investigated. With an IC50 value of 37.54 for complex 1a, it can be said that it is more cytotoxic to MCF-7 cells compared to other complexes, while the least cytotoxicity was observed in complex 1b.